Molecular Regulatory Networks of Life (R'Life) 2020–2023
Molecular Regulatory Networks of Life (R’Life) Academy Programme explores how various mechanisms create links between different parts of the genome and gene networks and how these links regulate life functions. The programme yields key information on networks that regulate the function of cells, tissues and individuals.
The aim of the Molecular Regulatory Networks of Life Academy Programme is to broaden our understanding of the function and structure of the genome. The programme provides more information on how various mechanisms create links between different parts of the genome and gene networks and how these connections regulate the functions of life. How do individual differences in genomes, for example, affect the ability of the body to adapt to acute and chronic stress? And what then happens inside the organism in terms of its internal molecular mechanisms? How do the mechanisms that regulate the interaction between the genome and environmental factors affect the phenotype?
The R’Life Academy Programme focuses on basic research in order to produce comprehensive key information on the networks that regulate the function of cells, tissues and individuals. Such comprehensive knowledge can be built by combining new molecular biology and bioinformatics tools. The study of regulatory networks is made possible by significant advances in genome-wide research methods that delve into different layers of information. The R’Life Academy Programme encourages and promotes the adoption of both new research methods and new scientific approaches across the Finnish research community and thereby contributes significantly to renewal in these disciplines. The programme’s consortia enable close cooperation between researchers of different disciplines, which makes it possible to explore new perspectives and, through a broader study of phenomena, achieve scientific breakthroughs in fundamental questions of biology. Another aim is to call attention to the opportunities presented by existing research infrastructures.
Materials
Projects
Molecular Regulatory Networks of Life (R’Life), consortia 2019
Funding period: 01.01.2020-31.12.2023
Funding: 6M€
Interplay of genome structure and metabolic network in adaptation (AdaGe)
- Paula Jouhten, VTT Technical Research Centre of Finland Ltd
- H Jussi Sakari Jäntti, VTT Technical Research Centre of Finland Ltd
- Ville Mustonen, University of Helsinki
- Esa Pitkänen, University of Helsinki
- Project description (pdf)
Levels of cell fate regulation (FateLevels)
- Pekka A. Katajisto, University of Helsinki
- Ville Paavilainen, University of Helsinki
- Maria Vartiainen, University of Helsinki
- Project description (pdf)
LincRNA Orchestrated Molecular Regulatory Networks of Human Immune Response (LincReg)
- Riitta Lahesmaa, University of Turku
- Laura Elo, University of Turku
- Project description (pdf)
The leukemic matrisome interface as a source of markers and targets for acute myeloid leukemia (ELMI)
- Taina Pihlajaniemi, University of Oulu
- Valerio Izzi, University of Oulu
- Jyrki Heino, University of Turku
- Project description (pdf)
Genomic compatibility as the backstop at the species boundary (xHARES)
- Jaakko Pohjoismäki, University of Eastern Finland
- Eric Dufour, University of Tampere
- Project description (pdf)
Forest Tree Evolution Via Expression Regulation (FOREVER)
- Tanja Pyhäjärvi, University of Oulu
- Katri Kärkkäinen, Natural Resources Institute Finland
- Jarkko Salojärvi, University of Helsinki
- Mikko Sillanpää, University of Oulu
- Project description (pdf)
Nucleomechanical regulation of cell states – from pluripotency to cancer (NucleoMech)
- Sara Wickström, University of Helsinki
- Johanna Ivaska, University of Turku
- Antti Mäkitie, University of Helsinki
- Project description (pdf)
Molecular regulatory Networks of Life (R’Life) 2019; call for Academy-funded researchers
Funding period: 01.01.2020-31.12.2022
Funding: 2M€
Integrative approach to minor spliceosome regulatory networks
- Mikko Frilander, University of Helsinki
- Project description (pdf)
- Seminar presentation 27.11.2020 (pdf)
Molecular regulatory networks of climate adaptation
- Timo Hytönen, University of Helsinki
- Project description (pdf)
- Seminar presentation 27.11.2020 (pdf)
Spectrum of smooth muscle cell and fibroblast subtypes in atherosclerosis
- Minna Kaikkonen-Määttä, University of Eastern Finland
- Project description (pdf)
- Seminar presentation 27.11.2020 (pdf)
Towards molecular-level understanding of fertilization and sexual selection
- Jukka Kekäläinen, University of Eastern Finland
- Project description (pdf)
- Seminar presentation 27.11.2020 (pdf)
A novel family-based sequencing approach and dissection of regulatory networks underlying a colour polymorphism
- Johanna Mappes, University of Jyväskylä
- Project description (pdf)
- Seminar presentation 27.11.2020 (pdf)
Single-cell transcriptome and mass cytometry profiling reveals the mechanism of embryonic leukocyte migration
- Pia Rantakari, University of Turku
- Project description (pdf)
- Seminar presentation 27.11.2020 (pdf)
Defining the essential downstream targets of the Myc proto-oncogene
- Jussi Taipale, University of Helsinki
- Project description (pdf)
- Seminar presentation 27.11.2020 (pdf)
Personalised Phenotypic Diagnostics to Benefit Lung Cancer Patients
- Emmy Verschuren, University of Helsinki
- Project description (pdf)
- Seminar presentation 27.11.2020 (pdf)
Steering group
Steering group of the R'Life Academy Programme (until 31 Dec 2024):
- Jorma Palvimo, Research Council for Biosciences Health and the Environment (chair)
- Marjo Yliperttula Research Council for Natural Sciences and Engineering
- Kirsi-Marja Oksman-Caldentey, Research Council for Biosciences Health and the Environment
- Markus Perola, Finnish institute for health and welfare
- Riitta Julkunen-Tiitto
- Timo Otonkoski,University of Helsinki
- Johanna Vilkki, Natural Resources Institute of Finland
More information
- Heikki Vilen, Programme Manager, tel. +358 295 335 135
- Sara Illman, Programme Manager, tel. +358 295 335 119
- Tiina Neuvonen, Coordinator, tel. +358 295 335 076
Our email addresses are in the format firstname.lastname(at)aka.fi.
