CompGenome: New computational techniques for analysing the structural and functional landscape of the mammalian genomes

Consortium leader: professor HEIKKI MANNILA
HIIT - Basic Research Unit, University of Helsinki

Other project leaders of the consortium: 
Leena Peltonen-Palotie, Academy professor, Department of Molecular Medicine, National Public Health Institute
Juha Kere, professor, Karolinska Institute and University of Helsinki, Biomedicum, University of Helsinki
Aarno Palotie, professor, Finnish Genome Center, University of Helsinki
Anu Jalanko, docent, Department of Molecular Medicine, National Public Health Institute

Doctoral students of the consortium: 
Lauri Eronen
Niina Haiminen
Jussi Kollin
Jaana Heino
Sampo Sammalisto
Reetta Rautiainen
Inkeri Majuri
 
Other researchers of the consortium: 
Aristides Gionis
Mikko Koivisto
Markus Perola 

Project desciption and main results:
The availability of large mass of genomic data will make it possible to study in detail the genomic landscape in humans and other mammalian organisms and to investigate the variation both within and between species. The CompGenome project will develop and apply computational tools for describing the genomic and functional variation between individuals and between species, and study the significance of these variations for the functions of genes.  This information will eventually be used to understand the potential relationships of such variations in the genome landscape and complex diseases.  In particular, the project will develop (a) tools for the hierarchical description of the haplotype structure of human (and other mammalian) genomes, (b) techniques for the identification of rearrangements, duplications, and other large-scale variations in genomes; (c) methods for trait cluster based multiple locus testing in complex traits, and (d) tools for analyzing the relationship between transcript profiles and sharing of genome segments.

Publications: