MICMAN scientific publications

Publications arising from the MICMAN funding during the time period 2003 - spring 2006 (n = 89)

 Agace, W. Tissue Tropic Effector T cells: Generation and therapeutic opportunities. Nature Reviews in Immunology. 2006 (Under commission).

Agace, W., and B. Homey. Lymphocyte homing to peripheral epithelial sites. In: B. Moser ed Chemokine Biology: Basic Research and Clinical Application (Volume 1). Series "Progress in Inflammation Research. Birkhäuser Verlag AG, Basel. 2006. 35-58.

Alitalo A, Meri T, Comstedt P, Jeffrey LA, Tornberg J, Strandin T, Lankinen H, Bergström S, Cinco M, Vuppala S, Akins D, and Meri S (2005 ) Expression of complement factor H binding proteins in Borrelia garinii isolated from patients with neuroborreliosis. Eur J Immunol., 35:3043-53

Alitalo A, Meri T, Chen T, Lankinen H, Cheng ZZ, Jokiranta S, Seppälä I, Lahdenne P, Hefty PS, Akins DR, and Meri S. Lysine-dependent Multi-point Binding of the Borrelia burgdorferi Virulence Factor OspE to the C-terminus of Factor H. J Immunol, 172: 6195-6201, 2004

Arvola T, Ruuska T, Keränen J, Hyöty H, Salminen S, Isolauri E. Rectal bleeding in infancy; clinical, allergologic and microbiologic examination. J Pediatr, in press.

Bengt Johansson-Lindbom, B., Svensson, M., Wurbel, M-A., Malissen, B., Márquez, G., and Agace, W. Selective generation of gut-tropic T cells in gut associated lymphoid tissue (GALT); requirement for GALT dendritic cells and adjuvant. J. Exp. Med. 2003. 198; 963-969.

Biedzka-Sarek, M., Venho, R., and Skurnik, M. 2005. Role of YadA, Ail and lipopolysaccharide in serum resistance of Yersinia enterocolitica serotype O:3. Infection and Immunity 73: 2232-2244.

Brooks CS, Vuppala SR, Jett AM, Alitalo A, Meri S, Akins DA. Complement regulator acquiring surface protein 1 (CRASP-1) imparts resistance to human serum in B. burgdorferi, J Immunol, 175: 3299-3308, 2005

Edelman S., S Leskelä, E Ron, J Apajalahti, TK Korhonen 2003. In vitro adhesion of an avian pathogenic Escherihcia coli O78 strain to surfaces of the chicken intestinal tract and to ileal mucus. Vet. Microbiol. 91:41-56.

Ericsson, A., Kotarsky, K, Sigvardsson, M., and Agace, W. Regulation of CCL25 in small intestinal epithelial cells; Cdx proteins enhance the activity of the CCL25 promotor. 2006. J. Immunol. 176 4642-3651

Erkkilä L, Laitinen K, Haasio K, Tiirola T, Jauhiainen M, Lehr HA, Aalto-Setälä K, Saikku P, Leinonen M. Heat shock protein 60 autoimmunity and early lipid lesions in chholesterol-fed C57BL/6Jbom mice during Chlamydia pneumoniae infection. Atherosclerosis, 177:321-328, 2004

Gueimonde M, Sakata S, Kalliomäki M, Isolauri E, Benno Y, Salminen S. Effect of Maternal consumption of Lactobacillus GG on transfer and establishment of faecal bifidobacterail microbiota in neonates. J Pediatr Gastroenterol Nutr 2006; 42: 166-70.

Harju T, Leinonen M, Nokso-Koivisto J, Korhonen T, Räty R, He Q, Hovi T, Mertsola J, Bloigu A, Rytilä P, Saikku P. Infection load in stable asthma: Non-random distribution of pathogenic bacteria and viruses in induced sputum or pharyngeal secretions of adults with stable asthma. Thorax 2006, (in press)

von Hertzen LC, Laatikainen T, Mäkelä MJ, Jousilahti P, Kosunen TU, Petäys T, Pussinen PJ, Haahtela T, Vartiainen E. Infectious burden as a determinant of atopy – a comparison between adults in Finnish and Russian Karelia. Int Arch Allergy Asthma (in press)

von Hertzen L, Haahtela T. Disconnection of man and the soil –reasons for the asthma and atopy epidemic? J Allergy Clin Immunol 2006;117:334-44.

von Hertzen L, Mäkelä M, Petäys T, Jousilahti P, Kosunen T, Laatikainen T, Vartiainen E, Haahtela T. Growing disparities in atopy between the Finns and the Russians –a comparison of two generations. J Allergy Clin Immunol 2006;117:151-57

von Hertzen L, Haahtela T. Signs of reversing trends in the prevalence of asthma.. Allergy 2005;60:283-92.

von Hertzen L, Haahtela T. Immunization and atopy: possible implications of ethnicity Review. J Allergy Clin Immunol 2004;113:401-6.

von Hertzen L, Haahtela T. Asthma and atopy - the price of affluence? Allergy 2004;59:124-37.

Huittinen T, Leinonen M, Tenkanen L, Virkkunen H, Mänttäri M, Palosuo T, Manninen V, Saikku P. Synergistic Effect of Persistent Chlamydia pneumoniae Infection, Autoimmunity, and Inflammation on Coronary Risk. Circulation. 107:2566-70, 2003

Isolauri E, Salminen S. Probiotics, Gut Inflammation and Barrier Function. Gastroenetrol Clin North Am 2005; 34: 437-50.

Jarva H, Hellwage J, Jokiranta TS, Lehtinen M, Zipfel PF, Meri S. The group B streptococcal beta and pneumococcal Hic proteins are structurally related immune evasion molecules that bind the complement inhibitor factor H in an analogous fashion. J Immunol, 172: 3111-8, 2004.

Jarva H, Ram S, Vogel U, Blom AM, Meri S. Binding of the complement inhibitor C4bp to serogroup B Neisseria meningitidis, J Immunol, 174:6299-6307, 2005.

Jernberg C, Sullivan Å, Edlund C, Jansson J. K. (2005) Monitoring antibiotic induced alterations in the human intestinal microflora and detection of probiotic strains by the use of T-RFLP. Applied and Environm Microbiol 71 (1): 501-506.

Johansson-Lindbom, B., Svensson, M., Pabst, O., Palmqvist, C., Marquez, G., Forster, R., Agace, W. Functional specialization of gut CD103+ dendritic cells in the regulation of tissue selective T cell homing. 2005. J. Exp. Med. 202 1063-1073

Jokiranta TS, Jaakola VP, Lehtinen MJ, Pärepalo M, Meri S, and Goldman A. Structure of Complement Factor H C-terminus reveals molecular basis of atypical hemolytic uremic syndrome. EMBO J, 2006, in press

Klemola T, Masyuk V, von Hertzen L, Haahtela T. Occurrence of atopy among Russian and Finnish school children. Allergy 2004;59:465-6.

Kolmonen, E., K. Sivonen, J. Rapala and K. Haukka. 2004. Diversity of cyanobacteria and heterotrophic bacteria in cyanobacterial blooms in Lake Joutikas, Finland. Aquatic Microbial Ecology 36:201-211.

Kukkonen M., M Suomalainen, P Kyllönen, K Lähteenmäki, H Lång, R Virkola, IH Helander, O Holst, TK Korhonen 2004. Lack of O-antigen is essential for plasminogen activation by Yersinia pestis and Salmonella enterica. Mol. Microbiol. 51:215-225.

Kukkonen M, Korhonen TK 2004. The omptin family of enterobacterial surface proteases/adhesins: from Housekeeping in Escherichia coli to systemic spread of Yersinia pestis. Int. J. Med. Microbiol. 294:7-14.

Laitinen K, Kalliomäki M, Poussa T, Lagström H, Isolauri E. Evaluation of diet and growth in children with and without atopic eczema: follow-up study from birth to four years. Brit J Nutr 2005; 94: 565-74.

Laitinen K, Hoppu U, Hämäläinen M, Linderborg K, Moilanen E, Isolauri E. Breast milk fatty acids may link innate and adaptive immune regulation: analysis of soluble CD14, prostaglandin E2 and fatty acids. Pediatr Res, in press.

Latvala J, von Hertzen L, Lindholm H, Haahtela T. Trends in prevalence of asthma and allergy in Finnish young men: a nationwide study from 1966 to 2003. BMJ 2005;330;1186-87.

Lehtonen A., Veckman V., Nikula T., Lahesmaa R., Kinnunen L., Matikainen S. and Julkunen I. Regulated expression of interferon regulatory factor (IRF) 4 during differentiation of human dendritic cells and macrophages. J. Immunol., 175, 6570-6579, 2005

Leino M, Alenius H, Fyhrquist-Vanni N, Wolff H, Reijula K, Hintikka EL, Salkinoja-Salonen M, Haahtela T, Mäkelä MJ. Intranasal Exposure to Stachybotrys chartarum Enhances Airway Inflammation in Allergic Mice. American Journal of Respiratory and Critical Care Medicine 2006; 173:512-18.

Lepistö, L., J. Rapala, C. Lyra, K. A. Berg, K. Erkomaa and J. Issakainen. 2005. Occurrence and toxicity of cyanobacterial blooms dominated by Anabaena lemmermannii P. RICHTER and Aphanizomenon spp. in boreal lakes in 2003. Algological Studies 117 (Cyanobacterial Research 6):315–328.

Lepistö, L., K. Lahti, J. Rapala, L. Villa and I. Sammalkorpi. 2005. Effects of fish removal on cyanobacteria and their toxicity in Lake Tuusulanjärvi, Southern Finland. Verh. Internat. Verein. Limnol. 29:473–477.

Lepistö, L., P. Kauppila, J. Rapala, M. Pekkarinen and L. Villa. Estimation of reference conditions for phytoplankton in a naturally eutrophic shallow lake. Hydrobiologia (in press).

Lähteenmäki K, Edelman S, Korhonen TK 2005 Bacterial metastasis: the host plasminogen system in bacterial invasion. Trends Microbiol. 13:79-85.

Lähteenmäki K, Kyllönen P, Partanen L, Korhonen TK 2005. Antiprotease inactivation by Salmonella enterica released from infected macrophages. Cell. Microbiol. 7:529-538.

Majander K, Anton L, Antikainen J, Lång H, Brummer M, Korhonen TK, Westerlund-Wikström B 2005. Extracellular secretion of polypeptides using a modified Escherichia coli flagellar secretion apparatus.Nature Biotechnol. 23:475-481.

Majander K, Korhonen TK, Westerlund-Wikström B 2005. Simultaneous display of multiple foreign peptides in the FliD capping and the FliC filament proteins of the Escherichia coli flagellum. Appl. Environm. Microbiol. 71:4263-4268.

Malmberg LP, Petäys T, Haahtela T, Laatikainen T, Jousilahti P, Vartiainen E, Mäkelä MJ. Exhaled nitric oxide in healthy nonatopic school-aged children: determinants and height-adjusted reference values. Pediatr Pulm 2006, in press  

Mann B, Orihuela C, Antikainen J, Gao G, Sublett J, Korhonen TK, Tuomanen E 2006. Multifunctional role of choline binding protein G in pneumococcal pathogenesis. Infect. Immun. 74:821-829.

Mannonen L, Kamping E, Penttila T, Puolakkainen M. IFN- g induced persistent Chlamydia pneumoniae infection in HL and Mono Mac 6 cells: Characterization by real-time quantitative PCR and culture. Microb Pathog, 36:41-50;2004

Meri T, Blom AM, Hartmann A, Lenk D, Meri S, Zipfel PF. The hyphal and yeast forms of Candida albicansbind the complement inhibitor C4bp. Infect Immun, 72: 6633-41, 2004

Meri T, Murgia R, Stefanel P, Meri S, Cinco M. Regulation of complement activation at the C3-level by pathogenic leptospires. Microb Pathog, 9:139-47, 2005

Meri T, Cutler SJ, Blom AM, Meri S, Jokiranta TS. Relapsing fever spirochetes Borrelia recurrentis and B. duttonii utilize C4b binding protein for complement evasion. Infect Immun, 2006, in press

Moverare R, Petäys T, Vartiainen E, Haahtela T. IgE reactivity pattern to timothy and birch pollen allergens in Finnish and Russian Karelia. Int Arch Allergy Immunol 2005;136:33-38

Oja Merja, Panu Somervuo, Samuel Kaski and Teuvo Kohonen Clustering of Human Endogenous Retrovirus Sequences with Median Self-Organizing Map. In WSOM'03 – Workshop on Self-Organising Maps, Hikibino, Kitakyushu, Japan, 11-14 September, 2003. Proceedings on CD-ROM. 2003.

Oja Merja, Göran O. Sperber, Jonas Blomberg, and Samuel Kaski. Grouping and Visualizing Human Endogenous Ret- roviruses by Bootstrapping Median Self-organizing Maps. In Proceedings of IEEE Symposium on Computational Intel ligence in Bioinformatics and Computational Biology. San Diego, California, USA, 7-8 October, 2004. pages 95-101, 2004.

Oja Merja, Göran O. Sperber, Jonas Blomberg, and Samuel Kaski. Self-organizing map-based discovery and visualization of human endogenous retroviral sequence groups. International Journal of Neural Systems, 15(3):163–179. 2005.

Oscarsson J, Harlos C, Arvidson S. Regulatory role of proteins binding to the spa (protein A) and sarS (staphylococcal accessory regulator) promoter regions in Staphylococcus aureus NTCC 8325-4.Int J Med Microbiol. 2005 Aug;295(4):253-66.

Oscarssoon J, Tegmark-Wisell, and Arvidson S. Coordinated and differential control of aureolysin (aur) and serine protease (sspA) expression in Staphylococcus aureus by sarA, rot and agr (RNAIII). Int. J. Med Microbiol. 2006 Apr. in press

Penttilä T, Tammiruusu A, Liljeström P, Vuola J, Sarvas M, Mäkelä PH, Puolakkainen M. DNA immunization followed by a viral vector booster induces protective immunity in Chlamydia pneumoniae mouse model. Vaccine, 22(25-26):3386-94;2004.

Karlsson-Kanth A, Tegmark-Wisell K, Arvidson S, Oscarsson J. Natural human isolates of Staphylococcus aureus selected for high production of proteases and alpha-hemolysin are sigma(B) deficient. Int J Med Microbiol. 2006 Mar 8;

Oscarsson J, Harlos C, Arvidson S. Regulatory role of proteins binding to the spa (protein A) and sarS (staphylococcal accessory regulator) promoter regions in Staphylococcus aureus NTCC 8325-4.Int J Med Microbiol. 2005 Aug;295(4):253-66.

Penttinen MA, Heiskanen KM, Mohapatra R, DeLay ML, Colbert RA, Sistonen L, Granfors K. Enhanced intracellular replication of Salmonella enteritidis in HLA-B27-expressing human monocytic cells: dependency on glutamic acid at position 45 in the B pocket of HLA-B27. Arthritis Rheum 2004: 50: 2255-2263.

Petäys T, von Hertzen L, Metso T, Rytilä P, Jousilahti P, Helenius I, Vartiainen E, Haahtela T. Smoking and atopy as determinants of sputum eosinophilia and bronchial hyperresponsiveness in adults with normal lung function. Respir Med 2003;97:947-54.

Pietilä T.E., Veckman V., Kyllönen P., Lähteenmäki K., ^{Korhonen T. K. and Julkunen I. Activation, cytokine production and intracellular survival of bacteria in Salmonella-infected human monocyte-derived macrophages and dendritic cells. J. Leukocyte Biol. 78, 909-920, 2005.}

Pinne M, Östberg Y, Comstedt P, and Bergström S. Molecular analysis of the channel-forming protein P13 and its paralog family 48 from different Lyme disease Borrelia species. Microbiology. 2004, 150: 549-559

Pinne M., K. Denker, E. Nilsson, R. Benz, and S. Bergström. 2006. The BBA01 protein, a member of paralog family 48 from Borrelia burgdorferi, is potentially interchangeable with the channel-forming protein P13. Accepted in J Bacteriol

Pouillot F, Derbise A, Kukkonen M, Foulon J, Korhonen TK, Carniel E 2005. Evaluation of O-antigen inactivation on Pla activity and virulence of Yersinia pseudotuberculosis harbouring the pPla plasmid. Microbiology 151:3759-3768.

Ram S, Cox AD, Wright JC, Vogel U, Getzlaff S, Boden R, Li J, Plested JS, Meri S, Stein DC, Richards JC, Moxon ER, and Rice PA. Neisserial lipooligosaccharide is a target for complement component C4b: inner core phosphoethanolamine residues define C4b linkage specificity. J Biol Chem. 278: 50853-50862, 2003.

Rapala, J., K. A. Berg, C. Lyra, R. M. Niemi, W. Manz, S. Suomalainen, L. Paulin and K. Lahti. 2005. Paucibacter toxinivorans gen. nov. sp. nov., a bacterium degrading cyclic cyanobacterial hepatotoxins microcystins and nodularin. International Journal of Systematic and Evolutionary Microbiology 55:1563–1568.

Rapala, J., A. Robertson, A. P. Negri, K. A. Berg, P. Tuomi, C. Lyra, K. Erkomaa, K. Lahti, K. Hoppu and L. Lepistö. 2005. First report of saxitoxin in Finnish lakes and possible associated effects on human health. Environmental Toxicology 20:331–340.

Rinne MM, Gueimonde M, Kalliomäki M, Hoppu U, Salminen SJ, Isolauri E. Similar bifidogenic effects of prebiotic-supplemented partially hydrolyzed infant formula and breastfeeding on infant gut microbiota. FEMS Immunol Med Microbiol 2005; 43: 59-65.

Salmi M, Jalkanen S. Lymphocyte homing to the gut: attraction, adhesion and commitment. Immunol Rev 206:100-13, 2005.

Salmi M, Adams D, Jalkanen S. Systematic manifestations of mucosal diseases: trafficking of gut immune cells to joints and liver. In Mucosal Immunology. Eds. Mestecky et al. Academic Press, 2004.

Seppänen M, Virolainen-Julkunen A, Kakko I, Vilkamaa P, Meri S. Myiasis during adventure sports race. Emerg Inf Dis, 10: 137-9, 2004

Sirén J., Pirhonen J., Julkunen I. and Matikainen S. IFN-a regulates TLR-dependent gene expression of IFN-a , IFN-b, IL-28 and IL-29. J. Immunol. 174, 1932-1937, 2005.

Stenstad, H., Ericsson, A., Svensson, M., Picarello, D., Briskin, M., Marquez, G, and Agace, W. CCR9 independent effector CD4+ T cell recruitment to the small intestinal lamina propria. 2006. Blood. Jan 3 (Epub ahead of print)

Stolen C, Marttila-Ischihara F, Koskinen K, Yegutkin G, Turja R, Bono P, Skurnik M, Hänninen A, Jalkanen S, Salmi M. Absence of an Endothelial Oxidase AOC3 Leads to Abnormal Leukocyte Traffic in Vivo. Immunity, 22:105-115, 2005

Strengell M., Lehtonen A., Matikainen S. and Julkunen I. IL-21 enhances SOCS gene expression and inhibits LPS-induced cutokine production in human monocyte-derived dendritic cells. J. Leukoc. Biol. In press, 2006.

Spoof, L., K. A. Berg, J. Rapala, J. S. Metcalf, K. Lahti, L. Lepistö, G. A. Codd and J. Meriluoto. First observation of cylindrospermopsin in the boreal environment (Finland). Environmental Toxicology (in press).

Suhonen J, Komi J, Soukka J, Lassila O, Viljanen MK. Interaction between Borrelia burgdorferi and immature human dendritic cells. Scand J Immunol 2003;58:67-75

Sävykoski T, Harju T, Paldanius M, Kuitunen H, Bloigu A, Wahlström E, Rytilä P, Kinnula V, Saikku P, Leinonen M. Chlamydia pneumoniae infection and inflammation in adults with asthma. Respiration, 71:120-5, 2004

Tammiruusu A, Haveri A, Pascolo S, Lahesmaa R, Stevanovic S, Rammensee H-G, Sarvas M, Puolakkainen M, Vuola JM. Clearance of Chlamydia pneumoniae Infection in H-2 class I-/- Human Leukocyte Antigen-A2.1 monochain transgenic mice. Scand J Immunol, 62:131-139;2005.

Thulin P, Johansson L, Low DE, Gan BS, Kotb M, McGeer A, Norrby-Teglund A. Viable group A streptococci in macrophages during acute soft tissue infections. PLoS Medicine in press, 2006.

Törmäkangas L, Erkkilä L, Korhonen T, Tiirola T, Bloigu A, Saikku P, Leinonen M. Effects of repeated Chlamydia pneumoniae inoculations on aortic lipid accumulation and inflammatory response in C57BL/6J mice. Infec Immun 73:6458-6466, 2005

Veckman V., Miettinen M., Matikainen S., Giacomini E., Coccia E. M. and Julkunen I. Lactobacilli and streptococci induce inflammatory chemokine production in human macrophages that stimulates Th1 cell chemotaxis. J. Leukocyte Biol. 74, 395-402, 2003.

Veckman V., Miettinen M., Pirhonen J., Sirén J., Matikainen S. and Julkunen I. Streptococci and lactobacilli differentially induce maturation and production of cytokines and chemokines in human monocyte-derived dendritic cells. J. Leukocyte Biol. 75, 764-771, 2004

Veckman V., Österlund P., Fagerlund R., Melén K., Matikainen S. and Julkunen I. TNF-a and IFN-a pretreatment enhances influenza A virus-induced chemokine gene expression in lung epithelial cells. Virology, 345, 96-104, 2006.

Yan Y, Silvennoinen-Kassinen S, Leinonen M, Saikku P. Methodological aspects affecting the infectivity of Chlamydia pneumoniae in cell cultures in vitro. J Microbiol Methods. Apr;61(1):127-30, 2005

Yan Y, Silvennoinen-Kassinen S, Leinonen M, Saikku P. Inhibitory effect of heparan sulfate-like glycosaminoglycans on the infectivity of Chlamydia pneumoniae in HL cells varies between strains. Microbes Infect. 2006 Jan 17;

Vähämiko S, Penttinen MA, Granfors K. Etiology and pathogenesis of reactive arthritis: Role of non-antigen presenting effects of HLA-B27. Arthritis Research & Therapy 2005: 7: 136-141.

Widhe M, Jarefors S, Ekerfelt C, Vrethem M, Bergström S, Forsberg P and Ernerudh J. Borrelia specific IFN-g and IL-4 secretion in CSF and blood during the course of Human Lyme borreliosis: relation to clinical outcome. J Inf Dis 2004, 189: 1881-1891

Östberg Y., Carrol JM, Pinne M, Rosa P and Bergström S. Pleiotropic effects of inactivating a carboxyl-terminal protease, CtpA, in Borrelia burgdorferi. J. Bacteriol. 2004 186: 2074-2084

Östberg Y, Bunikis I, Bergström S and Johansson J The etiological agent of Lyme disease, Borrelia burgdorferi, appears to contain only a few small RNA molecules. J Bacteriol. 2004 186:8472-8477

Österlund P., Veckman V., Sirén J., Klucher K.M., Matikainen S. and Julkunen I. Gene expression and antiviral activity of type I IFNs and IL-29 in virus-infected human monocyte-derived dendritic cells. J. Virol., 79, 9608-9617, 2005.